期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 142, 期 5, 页码 827-830出版社
WILEY
DOI: 10.1111/j.1365-2141.2008.07241.x
关键词
fibroblast activation protein alpha; mesenchymal stromal cells; surface protein marker
类别
Mesenchymal stromal cells (MSCs) have gained widespread popularity in cell therapy, but their development into clinical products has been impeded by the scarcity of cell-specific markers. We previously explored transcriptome and membrane proteome of MSCs, from which fibroblast activation protein alpha (FAP) was recognized as a prime surface marker candidate. The present study showed that FAP was constitutively expressed on MSCs, but not on other cells. FAP immunoselection yielded homogeneous MSCs from cryopreserved bone marrow (BM). These results suggest that FAP serves as a surface protein marker that can singly define MSCs from BM and possibly from other sources.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据