期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 141, 期 6, 页码 757-763出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2008.07119.x
关键词
heparin; warfarin; discovery
类别
Heparin and coumarins have been the mainstay of anticoagulant therapy throughout our working lives. As we stand on the threshold of a new era of anticoagulants it is timely to look back upon their discovery and development. Both have fascinating stories to tell. Jay McLean claimed to have discovered heparin whilst a medical student, although this is disputed. The story of warfarin leads us from a mysterious haemorrhagic disease of cattle to the development of a rat poison which became one of the most commonly prescribed drugs in history. Many people were involved in both stories and we owe them all a debt of gratitude.
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