期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 143, 期 2, 页码 248-252出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2008.07329.x
关键词
mantle cell lymphoma; sox11; nuclear expression; survival; proliferation
类别
资金
- Swedish Cancer Society
- Swedish Research Council
- Gunnar Nilsson Cancer Foundation
- Cancer Society in Stockholm
- Magnus Bergvall Foundation
- Karolinska Institutet Funds
- Stockholm County Council funds
Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.
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