期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 140, 期 3, 页码 324-326出版社
WILEY
DOI: 10.1111/j.1365-2141.2007.06946.x
关键词
dexamethasone; granulocyte-colony stimulating factor; lenalidomide; multiple myeloma; neutropenia
类别
Lenalidomide combined with dexamethasone has significant clinical activity in the treatment of multiple mycloma (W. In previous clinical trials lenalidomide-induced neutropenia was a frequent side-effect, often leading to treatment delays and dose reductions. We describe three MM patients treated with lenalidomide plus dexamethasone, which developed grade 3/4 neutropenia during the initial cycles, but without serious infection. Administration of granulocyte-colony stimulating factor (G-CSF) for 3 d prevented further neutropenia, treatment delays, dose reductions, or infectious complications during the following cycles. Consequently, G-CSF could be effective in preventing further neutropenia-related complications without compromising treatment efficacy in MM patients with lenalidomide-induced neutropenia.
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