期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 143, 期 5, 页码 632-640出版社
WILEY
DOI: 10.1111/j.1365-2141.2008.07386.x
关键词
haemarthroses; cartilage; synovial tissue (synovium); arthropathy; haemophilia
类别
Haemophilic arthropathy is joint damage evolving from recurrent joint bleeds that occur in patients suffering from the clotting disorder haemophilia. Insight into the pathogenetic mechanism of this blood-induced arthropathy yields possible treatment targets and modalities useful to reduce this invalidating co-morbidity of haemophilia. Joint bleeding leads to initially independent adverse changes in both the synovial tissue and the articular cartilage. These subsequently influence each other: the synovial inflammatory changes enhancing cartilage damage and vice versa. Consequently, effective treatment strategies will have to affect both pathways.
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