期刊
PHARMACEUTICALS
卷 3, 期 5, 页码 1311-1334出版社
MDPI
DOI: 10.3390/ph3051311
关键词
Replication checkpoint; ATR; ATM; chemotherapy; Chk1
ATR is an apical kinase in one of the DNA-damage induced checkpoint pathways. Despite the development of inhibitors of kinases structurally related to ATR, as well as inhibitors of the ATR substrate Chk1, no ATR inhibitors have yet been developed. Here we review the effects of ATR downregulation in cancer cells and discuss the potential for development of ATR inhibitors for clinical use.
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