期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 40, 期 3, 页码 300-316出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-009-0872-7
关键词
Autism; Specific language impairment; Cerebellum; Broca's area; Asymmetry
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [K08MH001573] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [P01DC003610, U19DC003610] Funding Source: NIH RePORTER
We performed cerebellum segmentation and parcellation on magnetic resonance images from right-handed boys, aged 6-13 years, including 22 boys with autism [16 with language impairment (ALI)], 9 boys with Specific Language Impairment (SLI), and 11 normal controls. Language-impaired groups had reversed asymmetry relative to unimpaired groups in posterior-lateral cerebellar lobule VIIIA (right side larger in unimpaired groups, left side larger in ALI and SLI), contralateral to previous findings in inferior frontal cortex language areas. Lobule VIIA Crus I was smaller in SLI than in ALI. Vermis volume, particularly anterior I-V, was decreased in language-impaired groups. Language performance test scores correlated with lobule VIIIA asymmetry and with anterior vermis volume. These findings suggest ALI and SLI subjects show abnormalities in neurodevelopment of fronto-corticocerebellar circuits that manage motor control and the processing of language, cognition, working memory, and attention.
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