期刊
BRITISH JOURNAL OF DERMATOLOGY
卷 167, 期 1, 页码 92-102出版社
WILEY
DOI: 10.1111/j.1365-2133.2012.10961.x
关键词
-
类别
资金
- Amgen Inc.
Background Psoriasis is a Th17/Th1-mediated skin disease that often responds to antitumour necrosis factor (TNF) alpha therapies, such as etanercept. Objectives To better define mechanisms by which etanercept improves psoriasis and to gain insight into disease pathogenesis. Methods We investigated the early biochemical and cellular effects of etanercept on skin lesions in responder patients prior to substantial clinical improvement (<= 4 weeks). Results By 1 week, etanercept acutely suppressed gene expression of the interleukin (IL)-20 subfamily of cytokines (IL-19, IL-20, IL-24), which were found to be predominantly epidermis-derived and which are implicated in stimulating epidermal hyperplasia. Additionally, by 1 week of therapy, suppression of other keratinocyte-derived products (chemokines, antimicrobial proteins) occurred, while suppression of epidermal regenerative hyperplasia occurred within 1-3 weeks. Th17 elements (IL-23p19, IL-12p40, IL-17A, IL-22) were suppressed by 3-4 weeks. In vitro, TNF alpha and IL-17A coordinately stimulated the expression of the IL-20 subfamily in normal keratinocytes. Conclusions Based on the rapid suppression of regenerative hyperplasia, chemokines and other keratinocyte-derived products, including the IL-20 subfamily, we propose that epidermal activation is a very early target of etanercept. As many of these keratinocyte markers are stimulated by TNF-alpha, their rapid downregulation is likely to reflect etanercept's antagonism of TNF-alpha. Additionally, decreased epidermal hyperplasia might result specifically from acute suppression of the IL-20 subfamily, which is also a likely consequence of etanercept's antagonism of TNF-alpha. Thus, the IL-20 subfamily has potential importance in the pathogenesis of psoriasis and therapeutic response to etanercept.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据