期刊
NATURE REVIEWS IMMUNOLOGY
卷 10, 期 10, 页码 688-698出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2851
关键词
-
类别
资金
- National Institute of Health [AR056296, AI088177]
- NIAMS Centers of Excellence for Influenza Research and Surveillance (CEIRS)
- American Lebanese Syrian Associated Charities (ALSAC)
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI088177] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR056296] Funding Source: NIH RePORTER
The immune response to viral infections is determined by a complex interplay between the pathogen and the host. Innate immune cells express a set of cytosolic sensors to detect viral infection. Recognition by these sensors induces the production of type I interferons and the assembly of inflammasome complexes that activate caspase-1, leading to production of interleukin-1 beta ( IL-1 beta) and IL-18. Here, I discuss recent progress in our understanding of the central roles of NOD-like receptors (NLRs) and inflammasomes in the immune response during viral infections. This information will improve our understanding of host defence mechanisms against viruses and provide new avenues for interfering in the pathogenesis of infectious diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据