期刊
NATURE REVIEWS IMMUNOLOGY
卷 10, 期 9, 页码 645-656出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2818
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资金
- Deutsche Krebshilfe
- Cancer Research Institute
- University of Tubingen
- National Institutes of Health
- Juvenile Diabetes Research Foundation
Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numerous developmental programmes in vertebrates. Dysregulation of these programmes can lead to malignant growth and cancer. This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights into their potential roles in cancer development.
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