期刊
ANALYTICAL CHEMISTRY
卷 87, 期 13, 页码 6718-6723出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b00853
关键词
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资金
- National Basic Research Program of China (973 Program) [2013CB934400, 2012CB932400]
- NSFC [61361160412, 31400860]
- Priority Academic Pro-gram Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Key Laboratory for Carbon-based Functional Materials Devices
We herein introduce a kind of fluorescent silicon nanoparticles (SiNPs) bioprobes, that is, peptides-conjugated SiNPs, which simultaneously feature small sizes (<10 nm), biological functionality, and stable and strong fluorescence (photoluminescent quantum yield (PLQY): as well as favorable biocompatibility. Taking advantage of these merits, we further demonstrate such resultant SiNPs bioprobes are superbly suitable for real-time immunofluorescence imaging of cancer cells. Meanwhile, malignant tumor cells could be specifically destroyed by the peptides-conjugated SiNPs, suggesting potential promise of simultaneous detection and treatment of cancer cells.
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