期刊
BRITISH JOURNAL OF CANCER
卷 111, 期 7, 页码 1255-1261出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2014.73
关键词
Eph receptors; brain cancer; glioma; glioblastoma (GBM); therapeutic targeting
类别
The dismal outlook for patients with the most aggressive and common form of adult brain cancer, glioblastoma (GBM), motivates a search for new therapeutic strategies and targets for this aggressive disease. Here we review the findings to date on the role of Eph family receptor tyrosine kinases and their ephrin ligands in brain cancer. Expression of the Eph family of cell surface proteins is generally downregulated to very low levels in normal adult tissues making them particularly attractive for directed therapeutic targeting. Recent Eph targeting studies in pre-clinical models of GBM have been very encouraging and may provide an avenue to treat these highly refractory aggressive tumours.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据