期刊
BRITISH JOURNAL OF CANCER
卷 111, 期 3, 页码 619-622出版社
SPRINGERNATURE
DOI: 10.1038/bjc.2014.301
关键词
micropapillary carcinoma; breast cancer; ductal carcinoma; prognostic factors; survival; histological special type; radiotherapy
类别
资金
- Houston Methodist Hospital
Background: Invasive micropapillary carcinoma (IMPC) is a variant of breast carcinoma with a higher propensity for lymph node metastases compared with invasive ductal carcinoma (IDC). Methods: Retrospective analysis of 636 IMPC and 297 735 IDC cases in the Surveillance, Epidemiology and End Results database comparing disease-specific survival (DSS) and overall survival (OS) between IMPC and IDC. Results: A higher percentage of IMPC cases (52.0%) had nodal metastases compared with IDC cases (34.6%). The 5-year DSS and OS for IMPC was 91.8% and 82.9%, respectively compared with 88.6% and 80.5% for IDC, respectively. For both IMPC and IDC, oestrogen-receptor positivity was associated with better survival, while having four or more positive lymph nodes or larger tumour size correlated with worse survival. Radiotherapy provided a survival benefit for both histological types. Conclusions: Despite IMPC's higher propensity for lymph node metastasis, IMPC has DSS and OS that compare favourably with IDC.
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