期刊
BRITISH JOURNAL OF CANCER
卷 112, 期 2, 页码 238-250出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2014.610
关键词
positron emission tomography (PET); imaging; oncology; cancer; hypoxia; radiotracer
类别
资金
- Cancer Research UK (CRUK)
- CRUK
- Chief Scientific Office
- Breast Cancer Research Foundation
- NIHR Cambridge Biomedical Research Centre
- Cancer Research UK [18097, 16466, 16465, 18974, 11359] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10163] Funding Source: researchfish
Hypoxia, a hallmark of most solid tumours, is a negative prognostic factor due to its association with an aggressive tumour phenotype and therapeutic resistance. Given its prominent role in oncology, accurate detection of hypoxia is important, as it impacts on prognosis and could influence treatment planning. A variety of approaches have been explored over the years for detecting and monitoring changes in hypoxia in tumours, including biological markers and noninvasive imaging techniques. Positron emission tomography (PET) is the preferred method for imaging tumour hypoxia due to its high specificity and sensitivity to probe physiological processes in vivo, as well as the ability to provide information about intracellular oxygenation levels. This review provides an overview of imaging hypoxia with PET, with an emphasis on the advantages and limitations of the currently available hypoxia radiotracers.
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