期刊
BRITISH JOURNAL OF CANCER
卷 111, 期 5, 页码 987-997出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2014.328
关键词
acrylamide; endometrial cancer; type-I endometrial cancer; cohort; nutrition
类别
资金
- Wereld Kanker Onderzoek Fonds (WCRF NL) [WCRF 2011/442]
- Health Research Fund (FIS) of the Spanish Ministry of Health [Exp PI11/01473]
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Health Research Fund (FIS) of the Spanish Ministry of Health, Regional Governments of Andalucia, Asturias, Basque Country, Murcia [6236]
- Navarra
- Catalan Institute of Oncology, La Caixa [BM 06-130]
- Red Tematica de Investigacion Cooperativa en Cancer (Spain) [RD12/0036/0018, RD06/0020/0091]
- Danish Cancer Society (Denmark)
- Ligue contre le Cancer, Institut Gustave Roussy, Mutuelle Generale de l'Education Nationale, Institut National de la Santeet de la Recherche Medicale (INSERM, France)
- Deutsche Krebshilfe, Deutsches Krebsforschungszentrum (DKFZ) and Federal Ministry of Education and Research (Germany)
- Hellenic Health Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro (AIRC) and National Research Council (Italy)
- Dutch Ministry of Public Health
- Welfare and Sports (VWS)
- Netherlands Cancer Registry (NKR)
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (The Netherlands)
- Nordic Center of Excellence in Food, Nutrition and Health-Helga (Norway)
- Swedish Cancer Society, Swedish Scientific Council and Regional Government of Skane and Vasterbotten (Sweden)
- Cancer Research UK, Medical Research Council (United Kingdom)
- MRC [MC_UU_12015/1] Funding Source: UKRI
- Cancer Research UK [16491, 14136] Funding Source: researchfish
- Medical Research Council [G1000143, MC_U106179471, G0401527, MC_UU_12015/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114, NF-SI-0512-10135] Funding Source: researchfish
Background: Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk. Methods: Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method. Results: No associations were observed between acrylamide intake and overall EC (n = 1382) or type-I EC risk (n = 627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n = 203). Conclusions: Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.
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