期刊
BRITISH JOURNAL OF CANCER
卷 108, 期 1, 页码 1-8出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2012.569
关键词
pancreatic ductal adenocarcinoma; hyaluronic acid; interstitial fluid pressure; stromal resistance; desmoplasia; hyaluronidase
类别
资金
- NCI [CA129537, CA161112, CA152249, CA159240]
- Giles W. and Elise G. Mead Foundation
Pancreatic ductal adenocarcinomas (PDAs) are notoriously aggressive and resistant to treatment. They distinguish themselves further by their robust fibroinflammatory, or desmoplastic, stromal reaction and degree of hypovascularity. Recent findings have revealed multiple mechanisms of stromal complicity in disease pathogenesis and resistance. In this review, we focus on altered physicomechanics as one mechanism of what we term as 'stromal resistance' in PDA. Extremely high interstitial fluid pressures and a dense extracellular matrix combine to limit the delivery and distribution of therapeutic agents. We discuss the genesis and consequences of altered fluid dynamics in PDA and strategies to restore them.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据