期刊
BRITISH JOURNAL OF CANCER
卷 109, 期 2, 页码 401-407出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2013.350
关键词
combination of platelet count and neutrophil to lymphocyte ratio; inflammation-based prognostic system; neutrophil to lymphocyte ratio; survival after surgery; systemic inflammatory response; thrombocytosis
类别
Background: This study investigated the usefulness of a novel inflammation-based prognostic system, named the COP-NLR (COmbination of Platelet count and Neutrophil to Lymphocyte Ratio), for predicting the postoperative survival of patients with colorectal cancer (CRC). Methods: The COP-NLR was calculated on the basis of data obtained on the day of admission: patients with both an elevated platelet count (>30 x 10(4) mm (-3)) and an elevated NLR (>3) were allocated a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. Results: Four-hundred and eighty patients were enrolled. Multivariate analysis of clinical characteristics selected by univariate analysis showed that the COP-NLR (1, 2/0) (odds ratio, 0.464; 95% confidence interval, 0.267-0.807; P = 0.007) had an association with cancer-specific survival, along with pathology, lymph node metastasis, the serum levels of carcinoembryonic antigen, C-reactive protein and albumin, and the Glasgow Prognostic Score. Kaplan-Meier analysis and log-rank test revealed that the COP-NLR was able to divide such patients into three independent groups (P<0.001). Conclusion: The COP-NLR is considered to be a useful predictor of postoperative survival in patients with CRC.
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