期刊
BRITISH JOURNAL OF CANCER
卷 109, 期 2, 页码 512-525出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2013.283
关键词
retinoblastoma; retina; photoreceptor; chromosome 6p; chromosome 1q; chromosome 16q
类别
资金
- UK Children's Eye Cancer Trust (CHECT)
- Birmingham Children's Hospital Research Foundation
- Birmingham Children's Hospital Department of Oncology
- National Institutes of Health Research (NIHR) [NIHR-RP-02-12-019] Funding Source: National Institutes of Health Research (NIHR)
- National Institute for Health Research [NIHR-RP-02-12-019] Funding Source: researchfish
Background: Mutation of the RB1 gene is necessary but not sufficient for the development of retinoblastoma. The nature of events occurring subsequent to RB1 mutation is unclear, as is the retinal cell-of-origin of this tumour. Methods: Gene expression profiling of 21 retinoblastomas was carried out to identify genetic events that contribute to tumorigenesis and to obtain information about tumour histogenesis. Results: Expression analysis showed a clear separation of retinoblastomas into two groups. Group 1 retinoblastomas express genes associated with a range of different retinal cell types, suggesting derivation from a retinal progenitor cell type. Recurrent chromosomal alterations typical of retinoblastoma, for example, chromosome 1q and 6p gain and 16q loss were also a feature of this group, and clinically they were characterised by an invasive pattern of tumour growth. In contrast, group 2 retinoblastomas were found to retain many characteristics of cone photoreceptor cells and appear to exploit the high metabolic capacity of this cell type in order to promote tumour proliferation. Conclusion: Retinoblastoma is a heterogeneous tumour with variable biology and clinical characteristics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据