期刊
BRITISH JOURNAL OF CANCER
卷 108, 期 3, 页码 638-643出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2012.589
关键词
Toll-like receptor 5; carcinoma; squamous cell carcinoma; oral tongue cancer
类别
资金
- Cancer Foundation of Northern Ostrobotnia
- Emil Aaltonen Foundation
- Mary and Georg C Ehrnroot Foundation
- Finnish Medical Foundation
- Orion-Farmos Research Foundation
- Academy of Finland
- Sigrid Juselius Foundation
- Finnish Dental Society Apollonia
Background: Toll-like receptor 5 (TLR5) is an immune receptor recognising bacterial flagellin. Activation of TLR5 results in cancer invasion and cytokine release. As certain bacteria have been linked to oral cancer, we wanted to study TLR5 expression in oral tongue squamous cell carcinoma (OTSCC). Methods: Samples from 119 patients with OTSCC were obtained, including 101 samples of adjacent normal lingual mucosa. The TLR5 histoscore (0-300) was assessed semiquantitatively by immunohistochemistry in a blinded manner. Results: Toll-like receptor 5 was expressed in 84 normal epithelia and 118 cancer samples. Expression of TLR5 was increased in cancer when compared with normal lingual epithelium (median histoscore 15 vs 135). In cancer, higher TLR5 was associated with age of >70 years at the time of diagnosis, female gender and disease recurrence. No association between TLR5 expression and tumour grade, stage or treatment was found. In multivariate analysis, TLR5 was an independent predictor of cancer mortality (hazard ratio (HR) 3.587, 95% confidence interval (CI) (1.632-7.882)) and disease recurrence (HR 4.455, 95% CI (2.168-9.158)). Conclusion: Toll-like receptor 5 has a previously undescribed role in the pathophysiology of OTSCC and might represent a link between bacteria and cancer. It could be a useful marker for predicting recurrence or survival of OTSCC patients.
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