期刊
BRITISH JOURNAL OF CANCER
卷 109, 期 2, 页码 307-311出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2013.339
关键词
colorectal cancer; PRRX1; epithelial-to-mesenchymal transition; EMT; metastasis
类别
资金
- CREST
- Japan Science and Technology Agency (JST)
- Funding Program for Next Generation World-Leading Researchers [LS094]
Background: Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. Methods: We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC. The clinical significance of PRRX1 was also examined on three independent CRC case sets. Results: PRRX1 induced EMT and the stem-like phenotype in CRC cells. In contrast to studies of breast cancer, abundant expression of PRRX1 was significantly associated with metastasis and poor prognosis in CRC. Conclusion: PRRX1 is an indicator of metastasis and poor prognosis in CRC cases. Further investigation is required to uncover the signalling network regulating PRRX1.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据