期刊
BRITISH JOURNAL OF CANCER
卷 108, 期 5, 页码 997-1003出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2013.24
关键词
pancreatic cancer; inflammation; therapy
类别
资金
- Wellcome Trust
- Cancer Research UK
- Cancer Research UK [11650, 12481] Funding Source: researchfish
- Chief Scientist Office [CAF/06/24] Funding Source: researchfish
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy associated with <5% 5-year survival, in which standard chemotherapeutics have limited benefit. The disease is associated with significant intra-and peritumoral inflammation and failure of protective immunosurveillance. Indeed, inflammatory signals are implicated in both tumour initiation and tumour progression. The major pathways regulating PDAC-associated inflammation are now being explored. Activation of leukocytes, and upregulation of cytokine and chemokine signalling pathways, both have been shown to modulate PDAC progression. Therefore, targeting inflammatory pathways may be of benefit as part of a multi-target approach to PDAC therapy. This review explores the pathways known to modulate inflammation at different stages of tumour development, drawing conclusions on their potential as therapeutic targets in PDAC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据