期刊
BRITISH JOURNAL OF CANCER
卷 107, 期 4, 页码 700-706出版社
SPRINGERNATURE
DOI: 10.1038/bjc.2012.330
关键词
miR-126; oral squamous cell carcinoma; angiogenesis; lymphangiogenesis; VEGF-A
类别
资金
- Japan Society for the Promotion of Science, Japan
- Grants-in-Aid for Scientific Research [22592232, 23593110, 23592717] Funding Source: KAKEN
BACKGROUND: MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain 7 (EGFL7). However, the role of miR-126 in cancer is controversial. METHODS: We examined the function of miR-126 in oral squamous cell carcinoma (OSCC) cells. Furthermore, a series of 118 cases with OSCC were evaluated for the expression levels of miR-126. RESULTS: MicroRNA-126 (miR-126) was associated with cell growth and regulation of vascular endothelial growth factor-A activity, and demethylation treatment increased expression levels of miR-126 and EGFL7 in OSCC cells. A significant association was found between miR-126 expression and tumour progression, nodal metastasis, vessel density, or poor prognosis in OSCC cases. In the multivariate analysis, decreased miR-126 expression was strongly correlated with disease-free survival. CONCLUSION: The present results suggest that miR-126 might be a useful diagnostic and therapeutic target in OSCC. British Journal of Cancer (2012) 107, 700-706. doi:10.1038/bjc.2012.330 www.bjcancer.com Published online 26 July 2012 (C) 2012 Cancer Research UK
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