期刊
BRITISH JOURNAL OF CANCER
卷 106, 期 6, 页码 1053-1061出版社
SPRINGERNATURE
DOI: 10.1038/bjc.2012.61
关键词
breast cancer; fertility; decision-making; young women; decision aid
类别
资金
- Cancer Council, New South Wales [RG 06-13]
- National Health and Medical Research Council of Australia (NHMRC) [350989, 1003921]
- Cancer institute NSW
- NHMRC [404094]
BACKGROUND: Fertility is a priority for many young women with breast cancer. Women need to be informed about interventions to retain fertility before chemotherapy so as to make good quality decisions. This study aimed to prospectively evaluate the efficacy of a fertility-related decision aid (DA). METHODS: A total of 120 newly diagnosed early-stage breast cancer patients from 19 Australian oncology clinics, aged 18-40 years and desired future fertility, were assessed on decisional conflict, knowledge, decision regret, and satisfaction about fertility-related treatment decisions. These were measured at baseline, 1 and 12 months, and were examined using linear mixed effects models. RESULTS: Compared with usual care, women who received the DA had reduced decisional conflict (beta = -1.51; 95% CI: -2.54 to 0.48; P = 0.004) and improved knowledge (beta = 0.09; 95% CI: 0.01-0.16; P = 0.02), after adjusting for education, desire for children and baseline uncertainty. The DA was associated with reduced decisional regret at 1 year (beta = -3.73; 95% CI: -7.12 to -0.35; P = 0.031), after adjusting for education. Women who received the DA were more satisfied with the information received on the impact of cancer treatment on fertility (P<0.001), fertility options (P = 0.005), and rated it more helpful (P = 0.002), than those who received standard care. CONCLUSION: These findings support widespread use of this DA shortly after diagnosis (before chemotherapy) among younger breast cancer patients who have not completed their families. British Journal of Cancer (2012) 106, 1053-1061. doi:10.1038/bjc.2012.61 www.bjcancer.com (C) 2012 Cancer Research UK
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