期刊
BRITISH JOURNAL OF CANCER
卷 104, 期 10, 页码 1649-1655出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2011.128
关键词
head-and-neck cancer; lung cancer; volatile biomarker; breath; sensor; GC-MS
类别
资金
- European Commission
- Israel Ministry of Science and Technology
- Israeli Council for Higher Education
BACKGROUND: Head-and-neck cancer (HNC) is the eighth most common malignancy worldwide. It is often diagnosed late due to a lack of screening methods and overall cure is achieved in <50% of patients. Head-and-neck cancer sufferers often develop a second primary tumour that can affect the entire aero-digestive tract, mostly HNC or lung cancer (LC), making lifelong follow-up necessary. METHODS: Alveolar breath was collected from 87 volunteers (HNC and LC patients and healthy controls) in a cross-sectional clinical trial. The discriminative power of a tailor-made Nanoscale Artificial Nose (NA-NOSE) based on an array of five gold nanoparticle sensors was tested, using 62 breath samples. The NA-NOSE signals were analysed to detect statistically significant differences between the sub-populations using (i) principal component analysis with ANOVA and Student's t-test and (ii) support vector machines and cross-validation. The identification of NA-NOSE patterns was supported by comparative analysis of the chemical composition of the breath through gas chromatography in conjunction with mass spectrometry (GC-MS), using 40 breath samples. RESULTS: The NA-NOSE could clearly distinguish between (i) HNC patients and healthy controls, (ii) LC patients and healthy controls, and (iii) HNC and LC patients. The GC-MS analysis showed statistically significant differences in the chemical composition of the breath of the three groups. CONCLUSION: The presented results could lead to the development of a cost-effective, fast, and reliable method for the differential diagnosis of HNC that is based on breath testing with an NA-NOSE, with a future potential as screening tool. British Journal of Cancer (2011) 104, 1649-1655. doi: 10.1038/bjc.2011.128 www.bjcancer.com Published online 19 April 2011 (C) 2011 Cancer Research UK
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