期刊
BRITISH JOURNAL OF CANCER
卷 104, 期 12, 页码 1890-1895出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2011.167
关键词
CIP2A; prognosis; survival; tongue cancer
类别
资金
- Finska Lakaresallskapet
- Finnish Cancer Society
- Finnish Dentists' Association Apollonia
- Helsinki University
- Kurt and Doris Palander Foundation
- Medicinska understodsforeninen Liv och Halsa
- Sigrid Juselius Foundation
- Suomalais-Norjalainen Laaketieteen Saatio
- Waldemar von Frenckell Foundation
- Weikko Wilhelm Peltonen Foundation
BACKGROUND: No reliable prognostic markers exist for squamous cell carcinoma of the tongue, and its prognosis can even in early stages be unpredictable and survival poor despite treatment. A potential marker is oncoprotein cancerous inhibitor of PP2A (CIP2A), which acts as a prognostic marker in gastric and non-small cell lung cancers. METHODS: We collected specimens of 73 stage T1N0M0 and T2N0M0 oral squamous cell carcinomas of the tongue, as well as samples from normal oral mucosa, dysplastic lesions, and invasive carcinomas (n = 39). All samples were stained for CIP2A by immunohistochemistry. Survival curves were constructed according to the Kaplan-Meier method. The Cox proportional hazard model served for univariate and multivariate survival analysis. RESULTS: High CIP2A immunoreactivity predicted poor survival in tongue cancer patients (P = 0.027, logrank test). In multivariate survival analysis, CIP2A was an independent prognostic factor (HR 2.02, 95% confidence interval 1.07-3.82, P = 0.030). Cytoplasmic CIP2A expression was higher in severe dysplasia than in mild dysplasia. CONCLUSION: Our results suggest that high CIP2A expression characterises aggressive disease. Acting as a prognostic marker it might be of help when choosing patients for adjuvant treatment in tongue cancer patients. British Journal of Cancer (2011) 104, 1890-1895. doi:10.1038/bjc.2011.167 www.bjcancer.com Published online 24 May 2011 (C) 2011 Cancer Research UK
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