期刊
BRITISH JOURNAL OF CANCER
卷 103, 期 4, 页码 505-509出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605784
关键词
cellular senescence; colorectal cancer; Ras mutations; treatment outcome
类别
资金
- Deutsche Krebshilfe [108789]
BACKGROUND: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown. METHODS: A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis. RESULTS: 5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044). CONCLUSION: Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed. British Journal of Cancer (2010) 103, 505-509. doi:10.1038/sj.bjc.6605784 www.bjcancer.com Published online 13 July 2010 (C) 2010 Cancer Research UK
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据