期刊
BRITISH JOURNAL OF CANCER
卷 104, 期 1, 页码 175-177出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605986
关键词
prostate cancer; hand pattern; case-control study
类别
资金
- Prostate Cancer Research Foundation
- Cancer Research UK [C5047/A8385]
- NIHR
- Royal Marsden NHS Foundation Trust
- Cancer Research UK [10118, 10588] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10096] Funding Source: researchfish
BACKGROUND: The ratio of digit lengths is fixed in utero, and may be a proxy indicator for prenatal testosterone levels. METHODS: We analysed the right-hand pattern and prostate cancer risk in 1524 prostate cancer cases and 3044 population-based controls. RESULTS: Compared with index finger shorter than ring finger (low 2D : 4D), men with index finger longer than ring finger (high 2D : 4D) showed a negative association, suggesting a protective effect with a 33% risk reduction (odds ratio (OR) 0.67, 95% confidence interval (CI) 0.57-0.80). Risk reduction was even greater (87%) in age group <60 (OR 0.13, 95% CI 0.09-0.21). CONCLUSION: Pattern of finger lengths may be a simple marker of prostate cancer risk, with length of 2D greater than 4D suggestive of lower risk. British Journal of Cancer (2011) 104, 175-177. doi:10.1038/sj.bjc.6605986 www.bjcancer.com Published online 30 November 2010 (C) 2011 Cancer Research UK
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