Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines

BACKGROUND/METHODS: This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection. RESULTS: HPV 16 and/or 18 was detected in 72% of cancers overall and in 82% of HPV-positive cancers. HPV 45 and 16 were the most frequently transcribed types. CONCLUSION: A significant reduction in ICC in Scotland should be achieved through the HPV immunisation programme. British Journal of Cancer (2010) 102, 930-932. doi: 10.1038/sj.bjc.6605556 www.bjcancer.com Published online 9 February 2010 (C) 2010 Cancer Research UK