Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2: ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status. British Journal of Cancer ( 2009) 100, 1603-1607. doi: 10.1038/sj.bjc.6605058 www.bjcancer.com Published online 28 April 2009 (C) 2009 Cancer Research UK