期刊
BRITISH JOURNAL OF CANCER
卷 100, 期 3, 页码 470-475出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604857
关键词
lung cancer; NSCLC; HOX; PBX
类别
资金
- Cancer Research-UK [7822/A383]
The HOX genes are a family of homeodomain-containing transcription factors that determine the identity of cells and tissues during embryonic development. They are also known to behave as oncogenes in some haematological malignancies. In this study, we show that the expression of many of the HOX genes is highly elevated in primary non-small-cell lung cancers (NSCLCs) and in the derived cell lines A549 and H23. Furthermore, blocking the activity of HOX proteins by interfering with their binding to the PBX co-factor causes these cells to undergo apoptosis in vitro and reduces the growth of A549 tumours in vivo. These findings suggest that the interaction between HOX and PBX proteins is a potential therapeutic target in NSCLC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据