期刊
BRITISH JOURNAL OF CANCER
卷 100, 期 8, 页码 1343-1346出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604977
关键词
prognosis; AML; mutations; CEBPA; risk assessment
类别
资金
- Swiss National Science Foundation [SF 310000 - 109388, SF 310000 - 113761]
CCAAT/enhancer binding protein alpha (CEBPA) mutations in AML are associated with favourable prognosis and are divided into N- and C-terminal mutations. The majority of AML patients have both types of mutations. We assessed the prognostic significance of single (n = 7) and double (n = 12) CEBPA mutations among 224 AML patients. Double CEBPA mutations conferred a decisively favourable overall (P = 0.006) and disease-free survival (P = 0.013). However, clinical outcome of patients with single CEBPA mutations was not different from CEBPA wild-type patients. In a multivariable analysis, only double - but not single - CEBPA mutations were identified as independent prognostic factors. These findings indicate heterogeneity within AML patients with CEBPA mutations.
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