期刊
BRITISH JOURNAL OF CANCER
卷 100, 期 6, 页码 870-873出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604971
关键词
gemcitabine; toxicity; CDA208G > A; pancreatic cancer; pharmacogenomics; polymorphism
类别
Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A [Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population.
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