期刊
BRITISH JOURNAL OF CANCER
卷 102, 期 1, 页码 1-7出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6605457
关键词
non-invasive biomarkers; magnetic resonance spectroscopy; metabolism; targeted therapeutics
类别
资金
- CRUK [CUK]
- EPSRC Cancer Imaging Centre, MRC
- Department of Health (England) [C1060/A10334, C1060/6916]
- NHS
Developing rational targeted cancer drugs requires the implementation of pharmacodynamic (PD), preferably non-invasive, biomarkers to aid response assessment and patient follow-up. Magnetic resonance spectroscopy (MRS) allows the non-invasive study of tumour metabolism. We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use. British Journal of Cancer (2010) 102, 1-7. doi:10.1038/sj.bjc.6605457 www.bjcancer.com Published online 24 November 2009 (C) 2010 Cancer Research UK
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