期刊
BRITISH JOURNAL OF CANCER
卷 100, 期 8, 页码 1230-1235出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604996
关键词
colorectal neoplasms; faeces/chemistry; guaiac; mass screening; occult blood; sensitivity and specificity
类别
资金
- French Ministry of Health
- INSERM National Health and Medical Research Institut
- French National 'Ligue contre le cancer'
We investigated variations in sensitivity of an immunochemical (I-FOBT) and a guaiac (G-FOBT) faecal occult blood test according to type and location of lesions in an average-risk 50- to 74-year-old population. Screening for colorectal cancer by both non-rehydrated Haemoccult II G-FOBT and Magstream I-FOBT was proposed to a sample of 20 322 subjects. Of the 1615 subjects with at least one positive test, colonoscopy results were available for 1277. A total of 43 invasive cancers and 270 high-risk adenomas were detected. The gain in sensitivity associated with the I-FOBT was calculated using the ratio of sensitivities (RSN) according to type and location of lesions, and amount of bleeding. The gain in sensitivity by using I-FOBT increased from invasive cancers (RSN = 1.48 (1.16-4.59)) to high-risk adenomas (RSN = 3.32 (2.70-4.07)), and was inversely related to the amount of bleeding. Among cancers, the gain in sensitivity was confined to rectal cancer (RSN = 2.09 (1.36-3.20)) and concerned good prognosis cancers, because they involve less bleeding. Among high-risk adenomas, the gain in sensitivity was similar whatever the location. This study suggests that the gain in sensitivity by using an I-FOBT instead of a G-FOBT greatly depends on the location of lesions and the amount of bleeding. Concerning cancer, the gain seems to be confined to rectal cancer.
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