期刊
BRITISH JOURNAL OF CANCER
卷 100, 期 9, 页码 1492-1498出版社
SPRINGERNATURE
DOI: 10.1038/sj.bjc.6605003
关键词
plant lignans; enterolignans; breast cancer risk
类别
资金
- Against Breast Cancer charity [1121258]
- ESRC [ES/G007438/1] Funding Source: UKRI
- Economic and Social Research Council [ES/G007438/1] Funding Source: researchfish
Phyto-oestrogens are plant compounds structurally similar to oestradiol, which have been proposed to have protective effects against breast cancer. The main class of phyto-oestrogens in the Western diet is lignans. Literature reports on the effect of lignans in breast cancer risk have been conflicting. We performed three separate meta-analyses to examine the relationships between (i) plant lignan intake, (ii) enterolignan exposure and (iii) blood enterolactone levels and breast cancer risk. Medline, BIOSIS and EMBASE databases were searched for publications up to 30 September 2008, and 23 studies were included in the random effects meta-analyses. Overall, there was little association between high plant lignan intake and breast cancer risk (11 studies, combined odds ratio (OR): 0.93, 95% confidence interval (95% CI): 0.83-1.03, P = 0.15), but this association was subjected to marked heterogeneity (I-2 = 44%). Restricting the analysis to post-menopausal women, high levels of plant lignan intake were associated with reduced breast cancer risk (7 studies, combined OR: 0.85, 95% CI: 0.78, 0.93, P < 0.001) and heterogeneity was markedly reduced (I-2 = 0%). High enterolignan exposure was also associated with breast cancer (5 studies, combined OR: 0.73, 95% CI: 0.57, 0.92, P = 0.009) but, again, there was marked heterogeneity (I-2 = 63%). No association was found with blood enterolactone levels (combined OR: 0.82, 95% CI: 0.59-1.14, P = 0.24). In conclusion, plant lignans may be associated with a small reduction in post-menopausal breast cancer risk, but further studies are required to confirm these results.
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