期刊
BRITISH JOURNAL OF CANCER
卷 98, 期 1, 页码 4-8出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604098
关键词
p53; Mdm2 ( hdm2); Mdm4 ( MdmX; Hdm4; HdmX); small molecule inhibitors
类别
The p53 pathway is aberrant in most human tumours with over 50% expressing mutant p53 proteins. The pathway is critically controlled by protein degradation. Here, we discuss the latest developments in the search for small molecules that can modulate p53 pathway protein stability and restore p53 activity for cancer therapy.
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