期刊
BRITISH JOURNAL OF CANCER
卷 99, 期 7, 页码 1096-1102出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604661
关键词
insulin-like growth factor-1; insulin-like growth factor-1 receptor; IGF binding protein 3; cervical cancer; cervical carcinoma
类别
资金
- National Science Council, Taiwan [NSC93-2320-B-006-028, NSC93-2314-B-006-020]
- National Health Research Institutes [NHRI-EX94-9311BS, NHRI-EX94-9422BI]
- Center for bioscience and biotechnology
- National Cheng Kung University
- Program for Promoting University Academic Excellence [91-B-FA09-1-4]
This study was aimed to identify the expression and the correlation of insulin-like growth factor-1 (IGF-1) system and their prognostic impacts in cervical cancer. Seventy-two patients with early-stage cervical cancer were eligible. We obtained the serum levels of total IGF-1 and IGF binding protein-3 (IGFBP-3) by enzyme-linked immunosorbent assay and the expression of IGF-1 receptor (IGF-1R) in cancerous tissue by immuno-fluorescent (IF) stains. The 5-year recurrence-free and overall survival rates were significantly lower (P = 0.003 and P = 0.01, respectively) among patients with high-grade expression of tissue IGF-1R, compared with those with low-grade expression. After adjustment for other factors, preoperative serum total IGF-1 or IGFBP-3 levels failed to predict cancer death and recurrence. High-grade expression of IGF-1R and elevated preoperative squamous cell carcinoma antigen level were independent predictors of both death and recurrence, and combination of both factors could further help identify the subgroup of patients at higher death risk. The IF staining indicates the colocalisation of IGF-1 and IGF-1R in the cancerous tissues, whereas the IGF-1R expression is not correlated with circulating levels of IGF-1 or IGFBP-3. In early-stage cervical cancer, IGF-1 system may have a paracrine or autocrine function and the adverse impacts on prognosis by IGF-1R overexpression are implicated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据