期刊
BRITISH JOURNAL OF CANCER
卷 98, 期 2, 页码 282-288出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6604170
关键词
ovarian cancer; progesterone receptor; SNPs; PROGINS; pooled analyses; endometrioid ovarian cancer
类别
资金
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [P30 CA014089, 5R01-CA080742, CA71966, R01 CA063464, CA63464, R01 CA074850, R01 CA080742, 5R01-CA074850, P30 CA016056, N01 PC067010, CA61132, CA16056, CA14089, R03-CA113148, R03 CA113148, P01 CA017054, N01-PC-6710, R01 CA 61107, U01 CA063464, CA17054] Funding Source: Medline
There is evidence that progesterone plays a role in the aetiology of invasive epithelial ovarian cancer. Therefore, genes involved in pathways that regulate progesterone may be candidates for susceptibility to this disease. Previous studies have suggested that genetic variants in the progesterone receptor gene (PGR) may be associated with ovarian cancer risk, although results have been inconsistent. We have established an international consortium to pool resources and data from many ovarian cancer case-control studies in an effort to identify variants that influence risk. In this study, three PGR single nucleotide polymorphisms (SNPs), for which previous data have suggested they affect ovarian cancer risk, were examined. These were +331 C/T (rs10895068), PROGINS (rs1042838), and a 30 variant (rs608995). A total of 4788 ovarian cancer cases and 7614 controls from 12 case-control studies were included in this analysis. Unconditional logistic regression was used to model the association between each SNP and ovarian cancer risk and two-sided P-values are reported. Overall, risk of ovarian cancer was not associated with any of the three variants studied. However, in histopathological subtype analyses, we found a statistically significant association between risk of endometrioid ovarian cancer and the PROGINS allele (n = 651, OR = 1.17, 95% CI = 1.01-1.36, P = 0.036). We also observed borderline evidence of an association between risk of endometrioid ovarian cancer and the +331C/T variant (n 725 cases; OR = 0.80, 95% CI 0.62-1.04, P = 0.100). These data suggest that while these three variants in the PGR are not associated with ovarian cancer overall, the PROGINS variant may play a modest role in risk of endometrioid ovarian cancer.
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