期刊
JOURNAL OF NUCLEIC ACIDS
卷 2010, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.4061/2010/840768
关键词
-
资金
- CNPq
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais-FAPEMIG (Brazil)
- Howard Hughes Medical Institute
A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies, the genome sequencing of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major, three related pathogens with different life cycles and disease pathology, has revealed interesting features of the DNA repair mechanism in these protozoan parasites, which will be reviewed here.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据