期刊
ANALYTICAL CHEMISTRY
卷 87, 期 17, 页码 8613-8617出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.5b02578
关键词
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资金
- National Basic Research Program of China (973 Program) [2013CB933800]
- National Natural Science Foundation of China [21422201, 21372018]
Two ratiometric probes fluoride ion, Mito-F and Lyso-F, were rationally designed and synthesized with positive charges at physiological conditions. The positive charges functioned as target moieties for subcellular mitochondria and lysosome of living cells, and effective sequesters of fluoride ion for fast and efficient fluorescent detection. In addition, in vivo imaging of fluoride ion in living mice was successfully achieved for the first time using probe Mito-F.
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