期刊
BRIEFINGS IN FUNCTIONAL GENOMICS
卷 11, 期 3, 页码 227-239出版社
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/els018
关键词
epigenetics; imprinting; DNA methylation; ZFP57; KAP1
资金
- BBSRC
- FP7 EpiHealth
- UK Biotechnology and Biological Sciences Research Council and European Commission [278418, BB/GO20930/1]
- Medical Research Council [MR/J001597/1] Funding Source: researchfish
- MRC [MR/J001597/1] Funding Source: UKRI
Epigenetic phenomena are being increasingly recognized to play key roles in normal mammalian development and disease. This is exemplified by the process of genomic imprinting whereby despite identical DNA sequence, the two parental chromosomes are not equivalent and show either maternal- or paternal-specific expression at a subset of genes in the genome. These patterns are set up by differential DNA methylation marking at the imprinting control regions in male and female germ line. In this review, we discuss the specific mechanisms by which these methyl marks are established and then selectively maintained throughout pre-implantation development. Specifically, we discuss the recent findings of a critical role played by a KRAB zinc-finger protein ZFP57 and its co-factor KAP1/TRIM28 in mediating both processes.
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