期刊
BRIEFINGS IN FUNCTIONAL GENOMICS
卷 9, 期 5-6, 页码 455-465出版社
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/elq035
关键词
epigenomics; next generation sequencing
资金
- US National Institutes of Health (NIH)
- NIH [5U01ES017154-02]
- Canadian Institutes of Health Research [92093]
Next generation sequencing has brought epigenomic studies to the forefront of current research. The power of massively parallel sequencing coupled to innovative molecular and computational techniques has allowed researchers to profile the epigenome at resolutions that were unimaginable only a few years ago. With early proof of concept studies published, the field is now moving into the next phase where the importance of method standardization and rigorous quality control are becoming paramount. In this review we will describe methodologies that have been developed to profile the epigenome using next generation sequencing platforms. We will discuss these in terms of library preparation, sequence platforms and analysis techniques.
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