期刊
BRIEFINGS IN BIOINFORMATICS
卷 14, 期 1, 页码 1-12出版社
OXFORD UNIV PRESS
DOI: 10.1093/bib/bbs007
关键词
bacteria; genomics; annotation; automatic; errors
资金
- Institute Strategic Programme grant by the Biotechnology and Biological Sciences Research Council (BBSRC)
- Institute for Animal Health
- Biotechnology and Biological Sciences Research Council [BBS/E/D/20231761, BBS/E/D/20211551, BBS/E/D/05191130, BBS/E/D/20310000] Funding Source: researchfish
- Medical Research Council [MR/K001744/1] Funding Source: researchfish
- BBSRC [BBS/E/D/05191130, BBS/E/D/20310000, BBS/E/D/20231761, BBS/E/D/20211551] Funding Source: UKRI
- MRC [MR/K001744/1] Funding Source: UKRI
With the development of ultra-high-throughput technologies, the cost of sequencing bacterial genomes has been vastly reduced. As more genomes are sequenced, less time can be spent manually annotating those genomes, resulting in an increased reliance on automatic annotation pipelines. However, automatic pipelines can produce inaccurate genome annotation and their results often require manual curation. Here, we discuss the automatic and manual annotation of bacterial genomes, identify common problems introduced by the current genome annotation process and suggests potential solutions.
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