期刊
BREAST JOURNAL
卷 16, 期 3, 页码 309-312出版社
WILEY
DOI: 10.1111/j.1524-4741.2010.00911.x
关键词
anthracyclines; chemoresistance; ixabepilone; metastatic breast cancer; taxanes
资金
- Bristol-Myers Squibb
With more and more breast cancer (BC) patients receiving taxanes and anthracyclines in the adjuvant setting, the number of patients resistant to these drugs is rising. Herein, we review cellular mechanisms (e.g., overexpression of drug efflux pumps) that are associated with clinical anthracycline and/or taxane-resistant BC. We also discuss therapeutic approaches that have received Food and Drug Administration approval in this setting or are in clinical development, including targeted agents that do not employ a cytotoxic mechanism, as well as novel chemotherapeutics such as the epothilones, a class of microtubule stabilizers less susceptible to common cellular resistance mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据