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The Mouse Retina as an Angiogenesis Model

期刊

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
卷 51, 期 6, 页码 2813-2826

出版社

ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/iovs.10-5176

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资金

  1. Deutsche Forschungsgemeinschaft ([DFG] AS)
  2. Canadian Institutes of Health Research
  3. Charles A. King Foundation (PS)
  4. Knights Templar Eye Foundation
  5. Children's Hospital Boston Manton Center for Orphan Disease Research's Innovation Fund (MCODR)
  6. Juvenile Diabetes Research Foundation International
  7. National Institutes of Health [EY008670, EY017017, EY14811]
  8. Roche Foundation for Anemia Research
  9. V. Kann Rasmussen Foundation
  10. Children's Hospital Boston Mental Retardation and Developmental Disabilities Research Center
  11. National Institute of Child Health and Development [P01 HD18655]
  12. Alcon Research Institute Award
  13. MacTel Foundation (LEHS)
  14. William Randolph Hearst Award
  15. March of Dimes Foundation
  16. Simeon Burt Wolbach Research Fellowship
  17. National Eye Institute [F32 EY017789]
  18. EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [P30HD018655] Funding Source: NIH RePORTER
  19. NATIONAL EYE INSTITUTE [F32EY017789, R01EY008670, R21EY014811, R01EY017017] Funding Source: NIH RePORTER

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The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. This article is a review of the angiogenic development of the mouse retina and a discussion of some of the most widely used vascular disease models. From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis. (Invest Ophthalmol Vis Sci. 2010; 51: 2813-2826) DOI:10.1167/iovs.10-5176

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