期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 133, 期 1, 页码 11-21出版社
SPRINGER
DOI: 10.1007/s10549-011-1855-x
关键词
IL-10; Breast cancer; Cytokine
类别
资金
- Indian Council of Medical Research (ICMR), Govt. of India [5/13/12/2007-NCDIII]
- Department of Biotechnology (DBT), Govt. of India
Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the intensity and duration of immune response by stimulating or inhibiting the activation, proliferation, and/or differentiation of target cells. Different cytokines are known to have diverse role in breast cancer initiation and progression. Interleukin-10 (IL-10), a pleiotropic anti-inflammatory cytokine, induces immunosuppression and assists in escape from tumor immune surveillance. Like several other cytokines, IL-10 also can exert dual proliferative and inhibitory effect on breast tumor cells indicating a complex role of IL-10 in breast cancer initiation and progression. In this review, we tried to put together a comprehensive current view on significance of IL-10 in promotion, inhibition, and importance as prognosticator in breast cancer based on in vitro, in vivo, and clinical evidences. For literature collection, we conducted PubMed search with keywords IL-10 and breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据