期刊
JOURNAL OF COMPARATIVE PATHOLOGY
卷 152, 期 2-3, 页码 211-216出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2014.12.013
关键词
defective collagen; dog; Ehlers-Danlos syndrome; vascular rupture
A 7-month-old male cross breed dog was presented with hyperextensible skin and atrophic scarring. A diagnosis of Ehlers Danlos syndrome was made based on clinical signs, histopathology and electron microscopy. Two weeks after presentation, the dog died suddenly. Post-mortem examination revealed haemothorax and rupture of the left subclavian artery. Histological findings, including Goldner's modified Masson's trichrome staining and transmission electron microscopy of the subclavian artery, revealed abnormalities in the structure and arrangement of collagen fibrils, suggesting that the defective collagen formation extended to the vasculature. To the authors' knowledge, this is the first report of Ehlers Danlos syndrome with vascular involvement in animals. (C) 2011 Elsevier Ltd. All rights reserved.
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