期刊
BREAST CANCER RESEARCH AND TREATMENT
卷 120, 期 3, 页码 769-775出版社
SPRINGER
DOI: 10.1007/s10549-009-0440-z
关键词
Telomere length; Blood leukocytes; Breast cancer; Biomarkers; Genetic susceptibility
类别
资金
- Susan G. Komen for the Cure [BCTR 0600562]
- National Institutes of Health [P30 CA51008, P30 CA016056]
- DOD [DAMD17-03-1-0446]
- NATIONAL CANCER INSTITUTE [P30CA051008, P30CA016056] Funding Source: NIH RePORTER
Telomere dysfunction, which leads to genomic instability, is hypothesized to play a causal role in the development of breast cancer. However, the few epidemiologic studies that assessed the relationship between telomere length in blood cells and breast cancer risk have been inconsistent. We conducted two case-control studies to further understand the role of telomere length and breast cancer risk. Overall telomere lengths were measured by telomere quantitative fluorescent in situ hybridization (TQ-FISH) and telomere quantitative real-time PCR (TQ-PCR). The associations between telomere length in blood leukocytes and risk of breast cancer were examined in two breast cancer case-control studies that were conducted at Roswell Park Cancer Institute (RPCI) and Lombardi Comprehensive Cancer Center (LCCC). Using the 50th percentile value in controls as a cut point, women who had shorter telomere length were not at significantly increased risk of breast cancer compared with women who had longer telomere length in the RPCI study (odds ratio [OR] = 1.34, 95% confidence interval [CI] = 0.84-2.12), in the LCCC study (OR = 1.18, 95% CI = 0.73-1.91), or in the combined RPCI and LCCC studies (OR = 1.23, 95% CI = 0.89-1.71). There was no significant dose-response relationship across quartiles of telomere length and no significant difference when comparing women in the lowest to highest quartile of telomere length. Overall telomere length in blood leukocytes was not significantly associated with the risk of breast cancer.
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