期刊
INTERNATIONAL JOURNAL OF RHEUMATOLOGY
卷 2010, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2010/923743
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资金
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [K23AR060241] Funding Source: NIH RePORTER
- NIAMS NIH HHS [K23 AR060241] Funding Source: Medline
Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis and autoimmune processes. Digital ischemia (digital ulcers (DUs)) is the hallmark of SSc-related vasculopathy and is characterized by endothelial dysfunction leading to intimal proliferation and thrombosis. It happens frequently (30% of the patients each year) and it is associated with significant morbidity. This paper summarizes the current information regarding pathogenesis, definitions, management, and exploratory therapies in DUs associated with SSc.
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