期刊
DERMATO-ENDOCRINOLOGY
卷 2, 期 1, 页码 9-16出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/derm.2.1.12490
关键词
hidradentitis suppurativa; acne inversa; autoimmune diseases; Crohn disease; spondylarthropathy; follicular occlusion; autoinflammatory disorders; Th17 cell cytokines
类别
Comorbidities of hidradenitis suppurativa (acne inversa) were reviewed by extracting original and review publications included in MEDLINE, EMBASE and COCHRANE libraries using the terms hidradenitis, Verneuil and acne inversa. Follicular occlusion disorders, inflammatory bowel diseases, especially Crohn disease, spondylarthropathy, other hyperergic diseases, genetic keratin disorders associated with follicular occlusion and squamous cell carcinoma were the most common hidradenitis suppurativa comorbid diseases. A first classification of these major comorbidities and their possible genetic background reveals a list of chromosome loci and genes, which could be hidradenitis suppurativa candidates. Most of these diseases belong to the group of autoinflammatory disorders, where Th17 cell cytokines seem to play a central role.
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